Dysfunction of circadian rhythm
Conditions
Interventions
Normal diet group:Circadian rhythm disorders, Normal diet
Meal replacement intervention group:Circadian rhythm disorders, Meal replacement intervention
Control group:None
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The subjects are healthy people; (2) Age between 18 and 80 years (age calculated as the difference between the date of screening survey and the date of birth); (3) Currently not participating in other research projects; (4) Signing informed consent; (5) Mental health and self-care; (6) Good compliance
Exclusion criteria
Exclusion criteria: (1) pregnant and lactating women; (2) It cannot guarantee sufficient time to participate in the project; (3) suffering from serious mental illness; (4) suffering from serious organic diseases such as cancer, coronary heart disease, myocardial infarction and stroke; (5) suffering from infectious diseases such as tuberculosis and AIDS; (6) Physical disability, or other reasons caused by the inability to take care of themselves; (7) Subjects with acute or chronic inflammatory diseases or infectious diseases, or who are receiving antibiotics, probiotics, probiotics, or any other medication that may affect the intestinal microbiome during the first 3 months of enrollment; (8) Use of antibiotics in the past 3 months for 3 days or more; (9) Patients with moderate or severe renal impairment (serum creatinine > 2mg/dL or 177mmol/L), or abnormal liver function (ALT>2 times the upper limit of normal); Moderate to severe chronic obstructive pulmonary disease; Patients with severe hypertension and cerebrovascular accidents; (10) complicated with severe cardiovascular, cerebrovascular, liver, kidney and hematopoietic diseases; (11) binge drinking (drinking more than 5 times a week, with an average of more than 2 liangjiu or half jin of yellow rice wine or 5 bottles of beer each time); (12) Patients who have received medication in the past 3 months for the following diseases: cholecystitis, digestive tract ulcers, urinary tract infections, acute pyelonephritis, cystitis, hyperthyroidism and other thyroid dysfunction; (13) Anemia: hemoglobin <10g/dl.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Islet function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal microbial composition and functional characteristics;Cognitive function;Anxiety and depression;hormone;Composition and functional characteristics of oral microorganisms;Composition and functional characteristics of skin microorganisms;Body fat;Immunity;Cerebrovascular function monitoring; | — |
Countries
China
Contacts
Public ContactHuijuan Yuan
He'nan Provincial People's Hospital
Outcome results
None listed