Neurodermatitis and chronic eczema
Conditions
Interventions
Piyanling liniment Group:Spraying Piyanling liniment on the affected skin twice a day, with a dosage of 0.5 ml/cm2 each time
Halcinonide solution Group:Applying Halcinonide solution on the affected skin twice a day, with a dosage of 0.5 ml/cm2 each time
Sponsors
the 71st Group Army Hospital of CPLA Army
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Neurodermatitis: The inclusion criteria for this study were as follows: patients who met the diagnostic criteria of Chinese Clinical Dermatology, presenting with skin lesions on the head, neck, upper limbs, elbows, palms, dorsal side of the hand, waist, back, lower legs, sacrococcygeal region, etc.; patients exhibiting the main clinical manifestation of itching, along with dense and patchy flat papules or papules that were fused and enlarged, resulting in lichenoid changes; patients aged between 18 and 70 years; patients with a disease duration of more than 1 month, limited range of skin lesions, and the total area of skin lesions not exceeding 10% of the body surface; patients who had not received any oral or topical medications, or other therapies prior to the visit; patients without any history of cardiovascular diseases, nervous system injuries, diabetes, tumors, tuberculosis, or other chronic diseases or mental illnesses. Chronic eczema: The patients met the diagnostic criteria for chronic eczema outlined in "Chinese Clinical Dermatology". The affected areas included the hands, feet, lower legs, elbows, and knees. The main clinical manifestations included thickening and infiltration of the skin, which presented with a brownish-red or grayish color, pigmentation, rough surface, and the presence of a few flaky scales resembling bran. Localized lichenification with clear borders was observed in varying degrees. Papules and vesicles were scattered around the periphery. The patients experienced significant paroxysmal itching, and the disease course exhibited a recurrent pattern. The age range of the patients was between 17 and 71 years. The total area of skin lesions occupied 10% or less of the total body surface area. There were no significant comorbid chronic diseases or mental illnesses observed.
Exclusion criteria
Exclusion criteria: Neurodermatitis: Pregnant or lactating women; skin lesions occurring on the face or external genitalia; skin lesions complicated by bacterial, viral, or fungal infections, or showing signs of systemic infection; occurrence of severe adverse events during treatment, non-compliance with medication instructions, or those deemed unsuitable to continue treatment, making it difficult to assess efficacy or safety due to incomplete data or other factors; patients who did not complete treatment according to the treatment plan; patients who voluntarily request to withdraw from the study. Chronic eczema: Skin lesions occurring in difficult-to-observe areas; patients with concurrent diseases where the skin lesions are not solely caused by chronic eczema; patients with major diseases of the heart, liver, spleen, lungs, kidneys, etc. in the past; pregnant women and breastfeeding women; patients with severe mental disorders who cannot communicate; patients who have recently used topical corticosteroids or other similar drugs; patients who did not comply with medication instructions during treatment, resulting in incomplete data or inability to determine efficacy; patients who self-administered other drugs without permission; patients who subjectively wish to withdraw from the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin lesion area;Skin lesion degree;Pruritus degree;Pigmentation degree;Clinical efficacy; | — |
Countries
China
Contacts
Public ContactYang Yang
the 71st Group Army Hospital of CPLA Army
Outcome results
None listed