polytrauma
Conditions
Interventions
T1 group:Add 100mg of nalbuphine to 50ml of normal saline at a concentration of 2mg/ml, and use a micropump pumping at 240ug/kg/h for continuous micropumping
T2 group:Add 1mg of remifentanil to 50ml of normal saline at a concentration of 20ug/ml, and use a micropump pumping at 1.2ug/kg/h for continuous micropumping
T3 group:(3)Add 100mg of nalbuphine to 50ml of normal saline at a concentration of 2mg/ml, and use a micropump pumping at 120ug/kg/h for continuous micropumping
add 1mg of remifentanil to 50ml of normal saline at a concentration of 20ug/ml, and use a micropump pumping at 0.6ug/kg/h for continuous micropumping
the two drugs are pumped simultaneously.
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: 18= Age =75 years old 2: Patients with polytrauma
Exclusion criteria
Exclusion criteria: (1) Allergies to opioids; (2) Pregnancy or lactation; (3) Patients With medical conditions that may affect the analgesia assessment; (4) Chronic opioid addiction or use of other analgesics for more than 3 months (5) Inability to obtain consent; (6) Patients automatically gave up treatment or died during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesia scores in each group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of TNF-a, IL-6, PCT, CRP, WBC and NEUTP in each group;Total analgesic drug use in each group;The adjustment of analgesic use in each group;Duration of mechanical ventilation;Length of stay in TSICU;Total length of stay;The incidence of adverse events incidence;Incidence of nausea and vomiting;Hypotension;Bradycardia (heart rate 100 beats/min);Respiratory depression (spontaneous breathing rate = 10 beats/min)/ apnea;Dizziness/headache;Pruritus and other adverse reactions; | — |
Countries
China
Contacts
Public ContactZhengtao Gu
The Third Affiliated Hospital of Southern Medical University
Outcome results
None listed