lower limb surgery
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients who need to use tourniquet during elective lower limb surgery in our hospital, such as knee arthroscopy, internal fixation of tibia and fibula, and knee joint replacement, can be enrolled in this study only if they meet the following conditions: 18 years old = age = 80 years old, regardless of gender; ASA is classified as I-III; 18 kg/m2=BMI=30kg/m2 Denied having serious cardio-cerebrovascular diseases; Sign the informed consent form (ICF) voluntarily, and are willing to abide by and expected to complete the test according to the requirements of the test protocol.
Exclusion criteria
Exclusion criteria: (1) The patient has chronic pain and takes opioid analgesics for a long time; (2) Blocking site infection; (3) Allergic to local anesthetic; (4) Combined with ischemic heart disease or uncontrolled hypertension, (5) tourniquet contraindication (peripheral neuropathy, peripheral vascular disease, etc.), (6) combined with mental disease, language disorder, inability to cooperate and serious hearing or visual impairment; (7) Long-term alcohol or drug dependence; (8) The accumulated time of tourniquet inflation is less than 45 minutes or more than 120 minutes; (9) Other conditions determined by the researcher to be unsuitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure fluctuation at various time points after tourniquet inflation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosage of nicardipine and esmolol during operation;Pain score and analgesic relief at each time point after surgery;The occurrence of postoperative nausea, vomiting, delirium and other adverse reactions; | — |
Countries
China
Contacts
The First Affiliated Hospital of University of Science and Technology of China