High-flow nasal cannula oxygen therapy versus non-invasive ventilation in emergency department patients with mild-to-moderate hypoxemia respiratory failure: a multicenter, randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077986

Enrollment

Unknown

Registered

2023-11-27

Start date

2023-11-27

Completion date

Unknown

Last updated

2023-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypoxic respiratory failure

Interventions

experimental group:nasal high-flow oxygen therapy

control group:Non invasive positive pressure ventilation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1: Arterial oxygen pressure less than 60mmHg with indoor air 2: or oxygenation index as 100-300mmHg 3: Age = 18 years old

Exclusion criteria

Exclusion criteria: 1: Immediate tracheal intubation is required 2: Consciousness (Glasgow coma score less than 9) 3: Hemodynamic instability and inability to be corrected by medication in the short term 4: pregnancy 5: Arterial blood carbon dioxide pressure = 50mmHg 6: Contraindications to the use of nasal high flow oxygen therapy or non-invasive ventilation 7: One of the non-invasive oxygen therapy devices was already in use during the visit 8: Other situations not suitable to enter clinical research by doctor's evaluation

Design outcomes

Primary

Measure	Time frame
Intubation rate;	—

Secondary

Measure	Time frame
Failure Rate;mortality;	—

Countries

China

Contacts

Public ContactYang Shuangyu

Beijing Hospital

yangshuangyu126@126.com+86 130 1113 5380

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026