postoperative delirium
Conditions
Interventions
Test group:The test group received low-dose esketamine short infusion treatment.
Control group:The control group received placebo (saline) short infusion therapy.
Sponsors
Affiliated Hospital of Jiaxing University(The First Hospital of Jiaxing )
Eligibility
Sex/Gender
All
Age
65 Years to 96 Years
Inclusion criteria
Inclusion criteria: Elderly patients undergoing noncardiac surgery under general anesthesia and transferred to the postanesthesia care unit (AICU) postoperatively, aged =65 years, of either sex, with ASA classification I-III, and a preoperative Fried Frailty Scale score of =3.
Exclusion criteria
Exclusion criteria: (i) preoperative delirium and cognitive dysfunction; (ii) preoperative central nervous system disease, psychiatric abnormalities or psychological disorders; (iii) patients with stroke or craniocerebral surgery; (iv) inability to complete neuropsychiatric function measurements prior to surgery; (v) allergy to or contraindication to esketamine and other study-related drugs; (vi) severe abnormalities of liver and renal function; (vii) previous history of PND; and (viii) those who refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of sedation (RASS score);sleep quality score (PSQI score);pain level (NRS score);The levels of inflammatory factors such as IL6, PCT, CRP, etc;Occurrence of adverse reactions; | — |
Countries
China
Contacts
Public ContactDeng Kang
Affiliated Hospital of Jiaxing University (The First Hospital of Jiaxing)
Outcome results
None listed