Infectious diseases
Conditions
Interventions
Gold Standard:clinically diagnosed as bloodstream infection or noninfectious fever
Index test:blood culture, blood mNGS, blood tNGS
Sponsors
Zhongshan Hospital, Fudan University, Shanghai, China
Eligibility
Sex/Gender
All
Age
14 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age = 14 years old, regardless of gender; 2) Meets the diagnostic criteria for systemic inflammatory response syndrome (SIRS); 3) Shivering and fever, with a body temperature greater than 38.5 ?; 4) At least one of the biomarkers increased: blood routine white blood cell count, C-reactive protein, erythrocyte sedimentation rate, and procalcitonin; 5) The infection is severe and suspected to be bloodstream infection which cannot be explained by local infection.
Exclusion criteria
Exclusion criteria: 1) When admitted, fever was clearly caused by non-infectious factors (such as tumors, rheumatic immune system diseases, etc.); 2) Unclear clinical diagnosis at discharge/death; 3) Patients who refuse to undergo blood culture, blood mNGS, blood tNGS; 4) Patients who are not suitable to participate in the study determined by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;Positive predictive value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactHu Bijie
Zhongshan Hospital, Fudan University, Shanghai, China
Outcome results
None listed