central precocious puberty
Conditions
Interventions
The group of three-month dose-form GnRHa:three-month dose-form GnRHa
The group of one-month dose-form GnRHa:one-month dose-form GnRHa
Sponsors
Fuzhou Children's Hospital in Fujian Province
Eligibility
Sex/Gender
All
Age
4 Years to 14 Years
Inclusion criteria
Inclusion criteria: (1) all are girls, And it conforms to the diagnostic criteria of central precocious puberty stipulated in the consensus of experts in the diagnosis and treatment of central precocious puberty; (2) Age of the child<14 years old; (3) this study was approved by the hospital ethics committee, and the parents of the children have informed consent to this study.
Exclusion criteria
Exclusion criteria: (1)Precocious puberty caused by organic lesions or other factors;(2)Patients with severe congenital disease or impaired hepatorenal function, or drug allergic reaction to GnRHa;(3))those who use estrogen drugs or drugs that affect the growth of children in the near future.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Staging of breast development;Staging of vulvar development; | — |
Secondary
| Measure | Time frame |
|---|---|
| Uterine volume;ovarian volume;Number of follicles;height;Bone Age;bone mineral density;body mass index; | — |
Countries
China
Contacts
Public ContactChen ruimin
Fuzhou Children's Hospital in Fujian Province
Outcome results
None listed