Stroke
Conditions
Interventions
Control group (Experiment 3):sham iTBS
Healthy Intervention group (Experiment 1):single iTBS
Healthy control group (Experiment 1):single sham iTBS
Stroke group (Experiment 2):none
Healthy control group(Experiment 2):none
Intervention group (Experiment 3):cerebellum iTBS
Sponsors
Changzhou De'an Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Stroke patients: (1) Diagnosed as supratentorial stroke according to the Chinese classification of cerebrovascular disease 2015 and were confirmed by MRI or CT; (2) First, unilateral onset and stable disease; (3) Unilateral paralysis; (4) Aged 18-80 years old; (5) The course of the disease was between 1-12 months; (6) Conscious and cooperative, cognitive ability, MMSE >= 20; (7) Brunnstrom III-V stage, (8) Orthostatic balance >= 1 grade, (9) Informed consent signed by family members and patients. 2. Healthy Subjects: (1) Aged 18-80 years old; (2) Former healthy, no serious nervous and motor system disease; (3)Right-handed; (4) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Cerebral stem and cerebellar stroke; 2. Patients with progressive stroke or malignant progressive hypertension, serious visceral system diseases, malignant tumors, etc.; 3. Previous history of organic brain diseases, mental disorders, epilepsy; 4. Patients with metal implantation or skull defect in the skull; 5. Treatment of local skin damage, inflammation or hyperalgesia in irritated areas; 6. The improved Ashworth score of the affected lower extremity was greater than grade 2. 7. Participants with vestibular dysfunction, those who exhibit an unusually strong response to transcranial magnetic stimulation, those taking medications known to influence the effects of transcranial magnetic stimulation, as well as individuals who have participated in transcranial magnetic stimulation interventions in the recent past
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| functional near infrared spectroscopy;Fugl-Meyer assessment sacle; | — |
Primary
| Measure | Time frame |
|---|---|
| Berg Balance scale;modified Barthel index;Mini-mental State Examination;gait speed ; | — |
Countries
China
Contacts
Public ContactShizhe Zhu, Tong Wang
Nanjing Medical University/Changzhou De'an Hospital
Outcome results
None listed