daytime painless abortion surgery
Conditions
Interventions
group RM1:Anesthesia was induced with esketamine combined with remimazolam 0.2mg/kg, and to determine the half effective dose of esketamine combined with different doses of remazolam to inhibit the bo
group RM2:Anesthesia was induced with esketamine combined with remimazolam 0.3mg/kg, and to determine the half effective dose of esketamine combined with different doses of remazolam to inhibit the bo
group RM3:Anesthesia was induced with esketamine combined with remimazolam 0.4mg/kg, and to determine the half effective dose of esketamine combined with different doses of remazolam to inhibit the bo
Sponsors
Yichang Central People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18-50 years old (2) BMI:18kg/?-30kg/? (3) ASA : I-II (4) Patients with 4-10 weeks of pregnancy and surgical indications for outpatient day-time painless abortion (5) The patient has informed consent to the surgical protocol and experimental protocol
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to anesthesia and surgery (2) Patients allergic to the use of anesthesia-related drugs (3) Patients who have taken other drugs that may affect the study before surgery (4) Patients who plan to combine other anesthesia methods (5) Hypertension, diabetes, cardiovascular and cerebrovascular diseases were not effectively controlled before surgery; Hyperthyroidism, asthma, elevated intraocular pressure or eye injury; Patients with mental system diseases; Craniocerebral injury patients; Abnormal liver and kidney function; Abnormal lipid metabolism; Patients in critical condition; Patients with myasthenia gravis (6) Patients with a known difficult airway ( Mallampati Score > ?) (7) Other special patients who are not suitable for participating in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| median effective dose;body movement response;adverse events;non-invasive blood pressure;heart rate;SPO2;sedation;drug use;vital signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Narcotrend index;visual analogue scale;BPS score;time of anesthesia induction;time of operation;time of awakening;time of leaveing the operating room;Modified MOAA/S score;Modified alderete score; | — |
Countries
China
Contacts
Public ContactChen Chun
Yichang Central People's Hospital
Outcome results
None listed