colonoscopy
Conditions
Interventions
remimazolam + esketamine group :Patients in remimazolam + esketamine group are given 0.3mg/kg esketamine and 0.15mg/kg remimazolam intravenously after 30 seconds
propofol + esketamine group :Patients in PE group were given 0.3mg/kg esketamine and 1.5mg/kg propofol intravenously after 30 seconds.
Sponsors
Zigong Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria include: (1) aged 65-85 years old; (2) American Society of Anesthesiologists (ASA) grades I - II; (3) Body mass index 18-24kg/m2.
Exclusion criteria
Exclusion criteria: Exclusion criteria include: (1) Abnormal liver and kidney function; (2) A history of alcohol or opioid abuse; (3) Use of benzodiazepines or analgesics within the past 3 months;(4) A history of contraindications or allergies to the drugs involved in this study; (5) Need to intubate or high risk of difficult airway (e.g. Mallampati score of 3 or 4); (6) Have mental illness or lack of cooperation; (7) Emergency surgery (such as acute gastrointestinal bleeding); (8) Further endoscopic treatment is required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cases and incidence of hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| The cases and incidence of hypertension, tachycardia and bradycardia;The cases and incidence of respiratory depression;The dosage of norepinephrine, urapidil, atropine and esmolol;Heart rate (HR) and mean arterial Blood pressure (MAP) at each time point;Single dose sedation success rate;The dosage of esketamine;The dosage of supplement drug and remedy drug ;Induction time of anesthesia;Awakening time;Exit time; Other adverse events; | — |
Countries
China
Contacts
Public ContactBoran Deng
Zigong Hospital of Traditional Chinese Medicine
Outcome results
None listed