Upper limb dysfunction in stroke, balance dysfunction in stroke, spinal cord injury, brachial plexus injury, and myocardial infarction
Conditions
Interventions
Balance dysfunction after cerebral infarction group:Cerebellar iTBS + Taijiquan
Upper limb dysfunction after cerebral infarction group:RTMS (target positioning) + upper limb robot
Walking dysfunction after SCI group:Cathodic HD-tDCS pretreatment combined with iTBS + lower limb multi-channel FES-assisted walking training
Peripheral paralysis of brachial plexus injury group:High-power composite spectrum therapy + routine rehabilitation training
Acute myocardial infarction group:Intelligent RIC training plan for the entire disease cycle under PCI surgical treatment + conventional treatment + internet mode
Sponsors
Suzhou City Dushu Lake Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Balance dysfunction of stroke: 1. Patients with stroke diagnosis by CT and / or MRI; 2. Primary, unilateral onset or no neurological dysfunction; 3. stable vital signs; 4. Age 40 to 70 years; 5. 1 year of disease; 6. Balance dysfunction, Berg score of 21-55; 7 Informed consent form was signed by the candidate or family members. Upper limb dysfunction in stroke: 1. Patients with cerebral infarction diagnosed by CT and / or MRI; 2. Primary, unilateral onset or no neurological dysfunction despite previous onset; 3. Stable vital signs; 4. Age 40 to 70 years; 5. 1 week to 3 months; 6. upper limb paralysis; 7. Participants or family members signed informed consent form . Spinal cord injury: 1. Patients with traumatic or non-traumatic incomplete spinal cord injury according to the ISNC SCI clinical diagnostic criteria; 2. T1-L2; 3. Age 18-65 years; 4. Stable vital signs and clear consciousness; 5. Course of 1~3 months; 6. Signed informed consent by patients or family members. Brachial plexus injury: 1. The brachial plexus injury caused by various injuries was confirmed by electromyography; 2. No age and gender; 3. Patients or family members signed the informed consent. Myocardial infarction: 1. New ST elevation myocardial infarction confirmed by clinical symptoms, ECG and laboratory tests 2. Symptoms; 16, can cooperate with rehabilitation treatment 6. Agree to participate in this trial and sign informed consent
Exclusion criteria
Exclusion criteria: Stroke balance dysfunction: 1. epileptic history, history of idiopathic epilepsy among first-degree relatives and use of epileptogenic drugs; 2. Severe cognitive and communication disorders but could not cooperate with evaluation and treatment; 3. Postcirculation stroke; 4. pacemaker wearing, intracranial metal implants, or skull defects; 5. balance dysfunction caused by other neurological diseases before onset; 6; vestibular dysfunction; 7. pregnant women, etc. Upper limb dysfunction of stroke: 1. epileptic history, history of idiopathic epilepsy in first-degree relatives and use of epileptogenic drugs; 2. severe cognitive and communication disorders unable to cooperate with assessment and treatment; 3. posterior circulation cerebral infarction; 4. pacemaker and intracranial metal implant; 5. severe cervical spondylosis including severe cervical stenosis and cervical instability; 6. Complete occlusion of internal carotid artery; direct injury and uncooperation in stimulation area and skull defect; 7. Patients with claustrophobia and non cooperative fMRI examination; 8. Pregnant women, etc. Spinal cord injury: 1. History of epilepsy, history of idiopathic epilepsy in first-degree relatives and use of epileptogenic drugs; 2. Severe mental illness, severe cognitive and communication disorders but cannot cooperate with evaluation and treatment; 3. cardiac pacemaker, intracranial metal implant, or skull defects; 4. Metal implants in lower limbs; 5. Cause of walking disorder is related to other neurological diseases; 6. Severe spasm, rigidity, contracture, contractures, osteoporosis and fracture; 7. Progressive spinal cord injury, etc. Brachial plexus injury: 1. Patients with severe heart, kidney and liver dysfunction; 2. Unawareness and mental disorders cannot cooperate; 3. Skin integrity damage, affecting assessors; 4. unable to accept the treatment; 5. Women during pregnancy and lactation. Myocardial infarction: 1. Previous ST elevation myocardial infarction or the ST elevation myocardial infarction 2. Previous coronary bypass transplantation 3. Previous stroke; 4.Have undergone thrombolytic therapy within 30 days; 5. History of cardiogenic shock; 6. persistent atrial fibrillation or atrial fibrillation 7. The existence of peripheral nerve disease, peripheral artery disease, thrombotic superficial phlebitis, acute venous thrombosis; 8. Emergency surgery is required due to serious complications such as ventricular septal rupture, free wall rupture, and acute severe mitral regurgitation; 9. Due to known malignant tumor or other serious systemic diseases cause life expectancy less than 12 months; 10. Contraindications to cardiac MRI imaging; 11. Have participated in other trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Berg Balance Scale;FMA-UE;LEMS lower extremity motor score;Standard score of brachial plexus injury function of Hand Surgery Society of Chinese Medical Association;6-minute walking distance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic and static balance function detection: stability index, total length of center of gravity movement trajectory, swing frequency, etc;Assessment of limb spasmodic status: a modified Ashworth scale score;Motor function: Simplified Fugl-Meyer motor function rating scale, Lower limb muscle strength, Berg balance scale;Pain: Digital grading method (NRS);The Seattle Anginal Pain Questionnaire (SAQ);Lower limb Fugl Meyer score;3m stand walk test;Activities of Daily Living Ability: ICF Universal Combination, Improved Barthel Index;fNIRS Brain Energy Assessment;Upper limb motor function: investigation and test scores of affected arm movements;MRI indicators: resting MRI, brain assessment;Activities of Daily Living: Improved Barthel Index, Injury Independence Assessment, ICF Universal Combination;Neuroelectrophysiological indicators: motor area mapping, MEPs amplitude, MEPs latency, and central motor conduction time SEP potential latency, SSR;Neuroelectrophysiological motor conduction velocity and CMAP amplitude, skin sympathetic response (SSR) amplitude, and latency affected muscle surface electromyography (iEMG, RMSMF);ICF Universal Combination;DLVEF, left ventricular end diastolic diameter;proBNP;CSF-36 Quality of Life Scale;Compliance (Completion); | — |
Countries
China
Contacts
Public ContactSu Min
Suzhou City Dushu Lake Hospital
Outcome results
None listed