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Effect and mechanism exploration of mirror neuron-based mirror therapy combined with repetitive transcranial magnetic stimulation on lower limb motor function after stroke

Effect and mechanism exploration of mirror neuron-based mirror therapy combined with repetitive transcranial magnetic stimulation on lower limb motor function after stroke

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077839
Enrollment
Unknown
Registered
2023-11-21
Start date
2022-06-09
Completion date
Unknown
Last updated
2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

B group:Routine rehabilitation+Mirror therapy
C group:Routine rehabilitation+rTMS
D group:Routine rehabilitation+Mirror therapy+rTMS

Sponsors

Sichuan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The patient was diagnosed as ischemic stroke by cranial CT or MRI, and the patient was diagnosed as ischemic stroke by first onset, with only one hemisphere injury, meeting the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke formulated by the Neurology Branch of the Chinese Medical Association in 2014; 2. During the study period, his condition was stable and his consciousness and consciousness were clear; 3. At the time of enrollment, the patients' sitting balance was greater than grade I, the lower extremity muscle tone was rated as modified Ashworth grade = 23, and there was no obvious cognitive dysfunction; 5. No diseases that can cause brain function changes, such as head trauma, intracranial infection, multiple sclerosis, etc.; 6. After the investigation of Chinese handedness criteria, it is judged to be right handedness; 7. The patient himself or his family members sign the informed consent voluntarily.

Exclusion criteria

Exclusion criteria: 1. Unstable vital signs; 2. Intracranial organic lesions (space occupation, vascular malformation, infection, trauma, congenital developmental abnormalities); 3. Cognitive dysfunction, mental disorders and incompatibility; 4. Patients with visual spatial impairment; 5. There are metal foreign bodies in the body or other conditions not suitable for MRI examination; 6. Previous history of stroke, epilepsy, dementia, depression history.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer assessment for lower extremity;Functional magnetic resonance imaging;

Secondary

MeasureTime frame
Berg’s balance scale;Modified Rivermead mobility index;Functional Ambulation Categories;10-Meter Walk Test;

Countries

China

Contacts

Public ContactWei Cui

Sichuan Provincial People's Hospital

CXW0516@163.com+86 181 2331 3125

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026