Tumors of the digestive system
Conditions
Interventions
Gold Standard:Multiple pathologists comprehensively evaluated the expression fraction of Claudin18.2 protein by immunohistochemistry
Index test:Artificial intelligence algorithms calculate the Claudin 18.2 antibody evaluation score, and calculate the artificial intelligence model to predict the expression status of Claudin 18.2 in
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: This is a prospective clinical study and we will enroll all cases that meet the inclusion criteria from December 2023 to December 2026. Inclusion Criteria: (1) Patients with primary digestive system tumors (including gastric cancer, gastroesophageal junction cancer and esophageal cancer, etc.); (2) Age= 18 years old and = 75 years old; (3) The included gross pathological specimens were not treated before surgery: including radiotherapy, chemotherapy, immunotherapy, etc.; (4) H&E pathological sections and claudin18.2 immunohistochemical slides were derived from the gross pathological samples based on surgical resection.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: (1) Pathological sections can be seen with large wrinkles and film drops; (2) The pathological section scan is not clear and does not focus accurately; (3) The patient's clinical pathological data is not perfect.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC;Sensitivity;Specificity;kappa; | — |
Countries
China
Contacts
Public ContactMuyan Cai
Sun Yat-sen University Cancer Center
Outcome results
None listed