lung cancer
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine group pumped dexmedetomidine 0.5ug/kg LBW 30 min before anesthesia (administered over 10 min) and injected an equal dose of saline 15 min before anesthesia.
Flurbiprofenate group: Flurbiprofenac group (group F) pumped an equal dose of saline 30 min before anesthesia and injected a slow intravenous drip of flurbiprofenac 1.0 mg/kg LBW 15 min before anesthe
Dexmedetomidine combined with flurbiprofenate group:dexmedetomidine combined with flurbiprofenate group (group D+F) pumped Dexmedetomidine 0.5ug/kg LBW 30 min before anesthesia (administered over 10 m
Control group:The control group pumped an equal dose of saline and a slow intravenous drip of flurbiprofenate 30 min before anesthesia. saline and an equal dose of saline was injected 15 min before an
Sponsors
the Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 64 Years
Inclusion criteria
Inclusion criteria: Obese patients with elective thoracoscopic right pneumonectomy for lung cancer using one-lung ventilation with a blocker were selected, regardless of gender, aged 35-64 years, with a BMI of 28.0-34.9 kg/m2, and ASA class I-II.
Exclusion criteria
Exclusion criteria: Preoperative history of severe cardiovascular or respiratory disease, history of narcotic analgesic drug abuse, history of psychiatric and neurological disorders, patients with peptic ulcers, patients with severe hepatic, renal, and hematologic dysfunction, patients with severe heart failure, hypertension, patients with a history of allergy to dexmedetomidine, flurbiprofen ester, patients with aspirin asthma or a previous history of aspirin asthma, patients who are on ilofloxacin, lomefloxacin , norfloxacin, patients applying non-steroidal anti-inflammatory drugs within 24h before surgery, contraindication to flurbiprofenate use, lactation. Contraindication to right lung sequestration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygen saturation;PaCO2;PaO2;OI; | — |
Secondary
| Measure | Time frame |
|---|---|
| The blood pressure;heart rate;Ppeak;Pmean;Cdyn;The ratio of ineffective lumen to tidal volume; | — |
Countries
China
Contacts
Public ContactHuanshuang Pei
the Fourth Hospital of Hebei Medical University
Outcome results
None listed