A clinical study of effect of CGF combined with autogenous bone on distal periodpntal tissue regeneration of mandibular second molar after extraction of impacted mandibular third molar

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077819

Enrollment

Unknown

Registered

2023-11-21

Start date

2021-10-20

Completion date

Unknown

Last updated

2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted mandibular third molar

Interventions

experimental group:Exsanguinate the patient s own blood to prepare for CGF and then put CGF into the extracion socket of mandibular second molar in the operating area after the extraction of fully-imp

control group:Directly suture the wound after the extraction of impacted mandibular third molar.

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1.The patient is aged from 18 to 50 years old with no limit of gender and needs the extraction of impacted mandibular third molar. 2.Bbilateral mandibular third molars are both impacted. 3.Good general health 4.Good oral hygiene and CPI is no more than 3 5.Voluntary participation and signing of informed consent.

Exclusion criteria

Exclusion criteria: 1.Adjacent second molar is III degrees loosened,fractured, or has incomplete root canal treatment history or severe apical inflammation causing it unable to keep. 2.Poor oral hygiene and CPI is more than 3 3.The operating area has acute inflammation such as pericoronitis or mandibular alveolar abscess. 4.There is dentigerous cyst or other oral maxilofical tumors around the patient's mandibular third molar. Or the patient is in the treatment of other oral and maxillofacial tumors. 5.The patient has an uncontrolled history of diabetes, alcohol abuse, blood disease, severe smoking, mental illness or other serious systemic diseases. 6.The patient is pregnant or in lactation 7.The patient is under orthodontic treatment. 8.The patient cannot follow doctor's orders and coorparate in the trial

Design outcomes

Primary

Measure	Time frame
Pain;Swelling;Wound Healing Index;Alveolar bone height;Alveolar bone density;	—

Secondary

Measure	Time frame
Concentration of growth factors and cytokines;	—

Countries

China

Contacts

Public ContactHuang Cheng

Department of Stomatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University

huangcheng@alumni.tongji.edu.cn+86 136 6179 1197

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026