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Efficacy and prognostic analysis of hepatectomy after preoperative therapy for patients with CNLC ?b~?a technically resectable hepatocellular carcinoma

Comparison of efficacy and safety between surgery following conversion therapy versus surgery alone in patients with surgically resectable hepatocellular carcinoma at CNLC IIb/IIIa stage

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300077818
Enrollment
Unknown
Registered
2023-11-21
Start date
2023-11-21
Completion date
Unknown
Last updated
2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cancer

Interventions

Comprehensive therapy group:NA
Surgery alone group:NA

Sponsors

Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: A Age 18-75 years old (including the cut-off value), male and female; B Postoperative pathological diagnosis of hepatocellular carcinoma; C Patients with Chinese liver cancer stage IIb or IIIa; D Surgically resectable after evaluation; E Liver function of Child-Pugh grade A or B; F Physical fitness status score ECOG 0-1; G Absence of extra-hepatic lesions and other contraindications to surgery, such as impairment of vital organ function due to systemic therapy; and H At least one image-measurable lesion according to the Modified Revised Evaluation Criteria for the Evaluation of the Efficacy of Solid Tumors (mRECIST).

Exclusion criteria

Exclusion criteria: A Patients with hepatocellular carcinoma with intrahepatic recurrence after prior radical resection; B Patients who had not adequately recovered from any intervention-induced toxicity or complications prior to initiating treatment; C Patients with a previous malignancy other than primary hepatocellular carcinoma within 5 years; D Missing pre-treatment liver imaging data; and E Incomplete follow-up data.

Design outcomes

Primary

MeasureTime frame
1-RFSR;

Secondary

MeasureTime frame
OS;ORR;DCR;MPR;AE;

Countries

China

Contacts

Public ContactKai Mao

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

maokai3@mail.sysu.edu.cn+86 159 2035 8201

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026