Hypoxemia
Conditions
Interventions
Esketamine intervention group:Esketamine maintains anesthesia
Refentanil control group:Refentanil maintains anesthesia
Sponsors
Hainan Ruijin Hospital (Boao Research Hospital) Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients who are at least 18 years old at the time of participation, with ASA grade I–III and BMI of 19-27 kg/m2, who are scheduled to undergo elective renal artery sympathetic ablation under basic anesthesia without intubation
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to esketamine or remifentanil. 2. Use of drugs that affect the central nervous system. 3. Chronic pain. 4. Severe ischemic heart disease; Heart failure (ejection fraction <40%). 5. Severe respiratory disease (spirometry and/or forced expiratory volume <50%). 6. Abnormal liver and kidney function. 7. History of neuropsychiatric illness or substance abuse. 8. Unable to cooperate with the scale assessment. 9. Pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypoxemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| OAAS score;Wake up time;Incidence of Intraoperative severe hypoxemia;Incidence of adverse events;Patient satisfaction; incidence of PONV ;Assessment of delirium in CAM;VAS score ;Two groups of drug dosage;Ramsay score; | — |
Countries
China
Contacts
Public ContactLixiong Chen
Hainan Ruijin Hospital (Boao Research Hospital) Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed