Homeostatic plasticity of brain in patients with disorder of consciousness detected by combined stimulation

Detecting the preservation of brain homeostatic plasticity in patients with disorders of consciousness through electromagnetic stimulation

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077784

Enrollment

Unknown

Registered

2023-11-20

Start date

2023-11-20

Completion date

Unknown

Last updated

2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorder of consciousness

Interventions

healthy control:(anodal/cathodal/sham) tDCS + iTBS

disorder of consciousness:(anodal/cathodal/sham) tDCS + iTBS

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: A. patients was assessed as a DoC patient by 5 times CRS-R ; B. patients with disease onset more than 28 day ; C. patient not have been affected by central nervous stimulants for 48 hours prior to stimulation ; D. patient not have used neuromuscular blockers for 24 hours prior to stimulation ; E. skin and anatomical structure of the target are intact ; F. right-handed, as verified using the Edinburgh Handedness Inventory;

Exclusion criteria

Exclusion criteria: A. patients with active seizures or a history of mental illness ; B. patients with intracranial indwelling metal objects, cranial bone flaps, and skull defects ; C. patients with unstable vital signs.

Design outcomes

Primary

Measure	Time frame
Motor evoked potential;	—

Secondary

Measure	Time frame
CRS-R;	—

Countries

China

Contacts

Public ContactDi Haibo

Hangzhou Normal University

2425574871@qq.com+86 176 8234 7063

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026