Colorectal cancer
Conditions
Interventions
Gold Standard:Colonoscopy and pathological findings
Index test:Human SDC2/SFRP2/TFPI2 Gene Methylation Combined Detection Kit (Fluorescent PCR method)
SDC2/SFRP2/TFPI2 methylation levels in fecal DNA
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were (1)(2)(3)(4) or (1)(2)(3)(5) or (1)(2)(3)(6) : (1) age =18 years and =75 years; (2) no history of colorectal cancer surgery or chemotherapy; (3) consent to participate in the trial; (4) prospective study subjects should meet the following requirements: subjects who are going to undergo colonoscopy and/or pathological examination; (5) retrospective study subjects: subjects with pathologically confirmed colorectal cancer or advanced adenoma; (6) the subjects in the interference group need to satisfy the following requirements: other digestive system tumors or non-digestive system tumors, such as liver cancer, esophageal cancer, gastric cancer, lung cancer, etc. .
Exclusion criteria
Exclusion criteria: (1) Patients with colon cancer with malignancy of other systems or multiple malignancies; (2) patients who had no means of sampling or were ineligible for samples; (3) patients with incomplete medical records (including sex, age, diagnostic information, colonoscopy and/or pathological diagnosis, other demographic data, etc.); (4) subjects who asked to withdraw from clinical trials; (5) patients who were not considered suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative and positive consistency rates of combined indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specificity;Sensitivity; | — |
Countries
China
Contacts
Public ContactGang Liu
Tianjin Medical University General Hospital
Outcome results
None listed