Advanced cancer pain
Conditions
Interventions
Oxycodone combined with dexmedetomidine group:Dexmedetomidine 0.5µg/kg was infused intravenously within 10min before operation, and then 0.2µg/(kg·h) was infused continuously until the end of operatio
fentanyl combined with dexmedetomidine group:Dexmedetomidine 0.5µg/kg was infused intravenously within 10min before operation, and then 0.2µg/(kg·h) was infused continuously until the end of operation
Sponsors
Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adult patients aged =18 years old, ASA II or III, with primary abdominal tumor who had poor analgesic effect of oral opioids (MS Contin =300mg/d, VAS=5 points at rest and burst pain>3 times/day) or could not tolerate side effects of high-dose opioids were selected from our hospital from December 2023 to August 2025.
Exclusion criteria
Exclusion criteria: Patients with severe cardiac and pulmonary dysfunction, severe bradycardia, poor control of hypertension, unstable angina pectoris, atrioventricular block above second degree, subarachnoid puncture taboos, allergy to dexmedetomidine , history of opioid abuse, unable to tolerate surgery or uncompleted surgery, unwilling to cooperate with researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure;VAS score;tumor necrosis factor a ; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;Ramsay score;pulse oxygen;cortisol;C-reactive protein;T lymphocyte subsets; | — |
Countries
China
Contacts
Public ContactXiaodi Sun
Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed