Application of remazolam combined with nerve block in elderly patients undergoing laparoscopic colorectal cancer surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077754

Enrollment

Unknown

Registered

2023-11-17

Start date

2023-11-30

Completion date

Unknown

Last updated

2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

control group:None

Nerve block group (N group):Bilateral transversal combined with rectus sheath nerve block was performed, and 10ml of 0.3% ropivacaine was injected into each point

Remazolam group (R group):0.2mg/kg/h remazolam besylate was pumped at a constant rate 10 minutes before anesthesia induction, adjusted to 0.1mg/kg/h after induction and maintained until 30 minutes bef

Remazolam combined with nerve block group (NR group):0.2mg/kg/h remazolam besylate was pumped at a constant rate 10 minutes before anesthesia induction, adjusted to 0.1mg/kg/h after induction and main

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: ?Age =60 years old, =75 years old ?ASAII or Level III ?BMI=28kg/?. ? To undergo laparoscopic colorectal cancer surgery ? Sign informed consent ? Gender unlimited ? Years of education =5 years

Exclusion criteria

Exclusion criteria: ? Complicated with serious cardiopulmonary disease ? Severe hepatic and renal insufficiency ? Allergic to benzodiazepines and remazolam ? Mental illness (5) Laparotomy was performed during the operation ? Preoperative consciousness or cognitive dysfunction The operation time is more than 6 hours ? Severe coagulation dysfunction

Design outcomes

Primary

Measure	Time frame
Systolic, diastolic, heart rate, mean arterial pressure;Blood sugar and lactic acid;Postoperative recovery quality and postoperative cognitive function status;VAS pain score and Ramasy sedation score;First time out of bed, first time to vent the anus, first time to eat, length of hospital stay;	—

Secondary

Measure	Time frame
Intraoperative dosage of propofol, remifentanil;The occurrence of adverse reactions such as nausea, vomiting, hypertension, hypotension, and drowsiness within 24 hours after surgery;Intraoperative hypotension, hypertension, tachycardia, bradycardia and other adverse reactions;Recovery time, extubation time, PACU residence time;Age, sex, BMI, ASA rating, previous history, mode of operation, time of operation, duration of anesthesia;	—

Measure

Time frame

Intraoperative dosage of propofol, remifentanil;The occurrence of adverse reactions such as nausea, vomiting, hypertension, hypotension, and drowsiness within 24 hours after surgery;Intraoperative hypotension, hypertension, tachycardia, bradycardia and other adverse reactions;Recovery time, extubation time, PACU residence time;Age, sex, BMI, ASA rating, previous history, mode of operation, time of operation, duration of anesthesia;

—

Countries

China

Contacts

Public ContactFang HaiYan

Guangxi Zhuang Autonomous Region People's Hospital

815117450@qq.com+86 189 7899 7117

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026