cancer pain
Conditions
Interventions
experimental group:PCA using hydromorphone
control group:PCA using morphine
Sponsors
The First Affiliated Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 18 to 80 years old, regardless of gender; 2. The patient is diagnosed as a malignant solid tumor through pathology or cytology; 3. Persistent and severe cancer related pain, VAS = 6; 4. ECOG performance status = 3; 5. Need to use opioid drugs and have not previously used opioid analgesics (Opioid naïve patients); 6. No cognitive impairment or psychiatric illness, and no radiotherapy, chemotherapy, or hormone, targeted, or bisphosphonate therapy within 7 days before randomization;7. Expected lifespan greater than 3 months; 8. Voluntarily participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are objections to the treatment method of this experiment; 2. Patients with abnormal coagulation function; 3. There are contraindications for the use of opioid drugs: paralytic intestinal obstruction, brain metastasis, severe liver and kidney failure, uncontrolled nausea or vomiting; 4. Previously used any opioid drugs; 5. Patients with severe mental or other illnesses who are unable to perform pain scores correctly or objectively describe symptoms; 6. Patients who cannot be followed up on schedule; 7. Individuals who are allergic to relevant drugs and excipients; 8. Pregnancy, renal failure, uremia, diabetes, multiple sclerosis and anemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid tolerance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage change in dose from baseline (dose change rate);Visual Analogue Scale / Score,VAS;The daily average breakthrough pain count;clinical success rate;36-item version of the Short Form Health Survey;Opioid Consumption; | — |
Countries
China
Contacts
Public ContactTao Song
The First Affiliated Hospital of China Medical University
Outcome results
None listed