Acquired Immune Deficiency Syndrome
Conditions
Interventions
probiotics+ART:probiotics+ART
ART:ART
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: Age was 18 (inclusive) -65 years old 2: HIV infection was confirmed by primary screening test and Western Blot confirmatory test 3: ART therapy were used for 1 year or more, and integrase inhibitor-based ART therapy regimens were used for the last 3 months 4: HIV viral load was less than 20copies/ml 5: CD4+T cells count was greater than or equal to 200 /mm3 and less than 500 /mm3 6: Informed consent was voluntarily signed, and regular follow-up and specimen collection and related treatment adverse reactions were guaranteed 7: Contraceptives were used from 4 weeks before the study to 4 weeks after the study
Exclusion criteria
Exclusion criteria: 1: Pregnant or lactating women, or planned pregnancy during the study observation period 2: Poor treatment compliance 3: under serious cardiovascular, respiratory, kidney, liver, brain or other basic diseases 4: Suffering from serious mental illness 5: Having a malignant tumor 6: suffering from active opportunistic infections 7: Allergic to study drugs or other contraindications to treatment 8: Unwilling to sign patient informed consent 9: Other conditions were not considered appropriate for inclusion in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bifidobacterium/Enterobacterium ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral blood HIV reservoir;sCD14;T cell subgroup; | — |
Countries
China
Contacts
Public ContactYimin Zhang
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed