Henoch-Schonlein Purpura Nephritis
Conditions
Interventions
HSP:NO
HSPN grade II group treated with integrated traditional chinese and western medicine:The treatment of traditional Chinese medicine is based on the principle of cooling blood and detoxification, promot
7-14 years old, one dose a day, twice a day. The specific prescriptions are as follows: Buffalo horn 15g, Radix Rehmanniae 10g, Cortex moutan 6g, Scutellaria baicalensis 10g, Radix Scutellariae 10g, t
damp-heat knot in middle coke, add patchouli 15g, Coix seed 12g
damp-heat knot in lower coke, add Phellodendron Phellodendron 10g, Camellia oleifera 9g.
The routine treatment scheme of HSPN western medicine: the routine treatment plan made by Nephrology Group of
HSPN grade II group treated with western medicine:The routine treatment scheme of HSPN western medicine: the routine treatment plan made by Nephrology Group of Chinese Medical Pediatrics Association i
Sponsors
The First Affiliated Hospital of Henan University of CM
Eligibility
Sex/Gender
All
Age
4 Years to 16 Years
Inclusion criteria
Inclusion criteria: (1) those who meet the above diagnostic criteria of HSP and HSPN in traditional Chinese medicine and western medicine. (2) all participants are between 4 and 16 years old. (3) the course of disease in children with HSP is less than 1 month, and there is no treatment before taking blood and urine samples. (4) the course of HSPN was less than 2 months. The pathological diagnosis of HSPN renal biopsy was HSPN ? and HSPN ?, mainly acute lesions. (5) TCM syndrome differentiation of children with HSP and HSPN belong to the syndrome of blood heat and blood stasis. (6) normal children: no abnormality in routine physical examination, no history of Henoch-Schonlein purpura and kidney disease. (7) all the children with HSPN agreed to undergo renal biopsy, and the children or their family members signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) patients with infection or other chronic diseases when collecting urine. (2) the amount of urine samples collected is too small. (3) transient abnormal urine test occurred in the course of HSP. (4) Children with HSP and HSPN had abnormal liver and kidney function in the course of disease. (5) Renal biopsy in children with HSPN showed mainly chronic pathological changes, such as segmental or globular sclerosis, fibrotic crescent, balloon thickening, balloon rupture, renal tubule atrophy and interstitial fibrosis. (6) for those who are allergic to drugs involved in the program. (7) those who have poor compliance and cannot take medicine according to the doctor's orders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-h proteinuria;Urine red blood cells;Urinalysis kidney damage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Six coagulation items;Tumor necrosis factor-a;Thrombin;Matrix Metalloproteinase-9;Type IV collagen;CD44; | — |
Countries
China
Contacts
Public ContactYan-jie Huang
The First Affiliated Hospital of Henan University of CM
Outcome results
None listed