Constipation in the elderly
Conditions
Interventions
placebo group:placebo
Sponsors
Chinese PLA General Hosptial
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) age =60 years; 2) BMI18.5-34.9 Kg/m2; 3) met the Roman criteria for IV constipation; ? must include 2 or more of the following: A. More than 1/4(25%) defecate with difficulty B. More than 1/4(25%) of the patients had dry or hard stools (Bristol Type 1-2) . C.More than 1/4(25%) of bowel movements were unsatisfactory. D.More than 1/4(25%) defecates had anorectal obstruction or obstruction. E.More than 1/4(25%) of defecation requires manual assistance (e. g. , finger-assisted defecation, pelvic floor support) . F.Spontaneous bowel movement (SBM) occurred less than 3 times per week ? rare feces without laxative ? pre-diagnosis symptoms occurred at least 6 months, nearly 3 months in line with the above diagnostic criteria. 4) volunteer to participate in the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) suffering from colorectal cancer, colorectal or anal stenosis, rectal mass or rectal overload, false intestinal obstruction, rectal giant, or other serious gastrointestinal diseases (gastric or duodenal ulcer, acute enteritis, ulcerative colitis, etc.) ; 2)history of major operations on the digestive system (such as gastrectomy, gastrointestinal suture, enterectomy, etc.); 3)suffering from severe cerebrovascular disease, neurological disease, endocrine/metabolic disease or infectious disease; 4)use of the following drugs within 1 month (enhancers, H2 receptor antagonist, Proton-pump inhibitor, anticonvulsants, opioid, chronic non-steroidal anti-inflammatory drug, antibiotics) ; 5)regular consumption of probiotics, probiotics, such as yoghurt, probiotic powder; 6) significant abnormality in blood pressureblood pressure, severe anemia; 7) excessive smoking, frequent alcohol abuse; 8) participation in other clinical studies within 1 month; 9) other conditions deemed inappropriate for participation in this study by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of spontaneous bowel movements per week; | — |
Secondary
| Measure | Time frame |
|---|---|
| Whole bowel transit time;Bristol Total Stool Trait Score;Total Constipation Symptom Score for Constipated Patients;Quality of Survival Scale for Constipated Patients;Cleveland Constipation Score;Intestinal metabolites;gut flora;Inflammatory cytokines;haematological metabolomics; | — |
Countries
China
Contacts
Public ContactYinghua Liu
Chinese PLA General Hosptial
Outcome results
None listed