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A study on the ED50 and ED95 of remifentanil required to suppress bronchoscopy response under sedation with ciprofol

A study on the ED50 and ED95 of remifentanil required to suppress bronchoscopy response under sedation with ciprofol

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077720
Enrollment
Unknown
Registered
2023-11-17
Start date
2023-11-17
Completion date
Unknown
Last updated
2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Interventions

Male group:Remifentanil
Female group:Remifentanil

Sponsors

The First Affiliated Hospital of Guangxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patient aged 60 to 90 years, ASA1-III grade, scheduled to undergo bronchoscopy under general anesthesia with laryngeal mask surgery, be sent to a recovery room for resuscitation after surgery.

Exclusion criteria

Exclusion criteria: 1 Patients with contraindications for bronchoscopy examination; 2 Patients with difficult airways; 3 Patients with severe airway stenosis and acute infection; 4 Patients with opioid allergy; 5 Patients with severe hypertension (systolic blood pressure = 180mmHg, or diastolic blood pressure = 110mmHg); 6 Patients with severe arrhythmia, manifested as (1) sinus bradycardia with a ventricular rate of<50 beats per minute (2) atrioventricular block or ventricular block of degree II or above; Or (3) other arrhythmias with a high risk of sinus arrest, such as sick sinus syndrome (SSS); 7 Patients classified as New York Heart Association (NYHA) Class III or above with severe heart failure; 8 Patients with liver dysfunction characterized by abnormal biochemical indicators of liver function; 9 Women in childbirth, childbirth, or lactation; 10 Patients whose preoperative consciousness state is difficult to independently or accurately determine; 11 Patients with a history of using psychotropic drugs; 12 And patients who meet any other criteria deemed unsuitable by the researchers for inclusion in this study.

Design outcomes

Primary

MeasureTime frame
Tracheal response rate during bronchoscopy examination;

Secondary

MeasureTime frame
Vital signs;Comfort;characteristic of anaesthesia and surgery;

Countries

China

Contacts

Public ContactXuehai Guan

The First Affiliated Hospital of Guangxi Medical University

guan_xh@aliyun.com+86 185 8769 7310

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026