polycystic ovarian syndrome
Conditions
Interventions
NAC group: During routine letrozole +uFSH ovulation stimulation, orally administrate NAC 1.8g/d daily (Usage: 0.6g, po, tid)
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
21 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1.the age of female partners were between 21~38 years old; 2. The cause of infertility in both spouses was diagnosed as ovulation disorder related to the woman's PCOS; 3. Previous ovulation induction treatment =2 cycles; 4. BMI=18.5, 15×106/ml, PR=32%, NR+NP: =40%.
Exclusion criteria
Exclusion criteria: 1, non-PCOS ovulation disorders or infertility caused by other factors; 2. Patients who have used oral contraceptives, metformin, inositol, n-acetylcysteine and other drugs in the past three months; 3, there are uterine malformations, uterine adhesions, submucous myoma and other conditions; 4. Patients with medical and surgical diseases complicated by pregnancy or drug treatment, including but not limited to uncontrolled diabetes, hypertension, liver disease, kidney disease, thyroid disease, adrenal disease, autoimmune disease, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ovulation rate per cycle;the incidence rate of OHSS;early pregnancy loss rate; | — |
Countries
China
Contacts
Public ContactYanhui Li
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed