tuberous sclerosis complex
Conditions
Interventions
Center group:The patient will undergo a course of low-intensity transcranial focused ultrasound treatment. The course consists of continuous treatment for 14 days, with each treatment session lasting
Center and perituberal tissue group:The patient will undergo a course of low-intensity transcranial focused ultrasound treatment. The course consists of continuous treatment for 14 days, with each tre
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for TSC (clinical and/or genetic) revised by the International TSC Alliance in 2012; (2) Meet the diagnostic criteria for refractory epilepsy: after regular treatment with two or more anti-epileptic drugs, the frequency of seizures is still not completely controlled; (3) Good compliance of subjects, able to cooperate to complete treatment and follow-up requirements; (4) The subject and their family members agree to participate in the study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with severe systemic diseases such as heart, brain, liver, kidney, blood, autoimmune diseases, chronic severe infections, etc.; (2) Contraindication to magnetic resonance imaging (MRI) (presence of metal implants in the body); (3) Currently participating in other interventional clinical trials; (4) Other reasons that the researcher considers inappropriate for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of seizures; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive outcomes;Anxiety and depression;Epileptic EEG signals; | — |
Countries
China
Contacts
Public ContactLei Chen
West China Hospital, Sichuan University
Outcome results
None listed