Reflux esophagitis
Conditions
Interventions
ARMS group:ARMS
ARMA group:ARMA
ARML group:ARML
Sponsors
Binzhou Medical University Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) 18 to 75 years old (including 18 and 75 years old), regardless of gender; (2) received double dose PPI treatment for at least 6 months, but still had typical reflux symptoms at least twice a week; (3) gastroscopy and imaging examination met GERD standard; gastroscopy results before ARMI (LA standard); (3) esophageal hiatal hernia = 3cm. (4) pathological acid reflux was diagnosed by 24-hour esophageal pH monitoring before ARMI (defined as DeMeester score > 14.7 or acid exposure time (AET) > 4.2%); (5) able to understand the information provided and be able to comply with the requirements of the scheme; (6) voluntarily agreed to participate in this clinical trial and signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) giant sliding hernia of esophageal hiatal hernia (> 3cm sliding hiatal hernia, confirmed by one or more examinations, including endoscopy, imaging, and manometry); (2) severe systemic diseases such as Parkinson's disease, scleroderma, Sjogren's syndrome, etc.; (3) previous upper gastrointestinal surgery; (4) history of digestive system tumors and other malignant tumors. (5) patients with severe heart, liver, lung, kidney, blood, or serious diseases affecting their survival; those who could not tolerate gastroscopy, intubation, and severe hemagglutination tendency; (6) pregnant and lactating women; (7) could not cooperate to complete the research process; (8) participated in other clinical medical studies in the past 3 months; (9) the doctor judged that it was not suitable to participate in this researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Esophagogastroduodenoscopy, EGD;High resolution pressure measurement;24-hour PH detection + impedance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of GERD-HRQL ;12-lead electrocardiogram;Symptom Assessment Questionnaire;Helicobacter pylori infection test; | — |
Countries
China
Contacts
Public ContactChen Yan
Binzhou Medical University Hospital
Outcome results
None listed