Acute myeloid leukemia (AML)
Conditions
Interventions
case series:None
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Newly diagnosed AML patients WHO meet the WHO 2022 diagnostic criteria (except APL) (2) Age =18 years old, gender unlimited (3) Obtain the results of second-generation sequencing gene mutation detection. Including but not limited to FLT3-ITD, NPM1, CEBPA, TP53, RUNX1, ASXL1, BCOR, EZH2, SF3B1, SRSF2, STAG2, U2AF1, ZRSR2, IDH1, IDH2, DNMT3a, C-kit (4) Obtain fusion gene test results, including but not limited to PML-RARa, RUNX1-RUNX1T1, CBFß-MYH11, MLLT3-KMT2A, MLL rearrangement, BCR-ABL1, DEK-NUP214, MECOM(EVI1) rearrangement (5) Physical strength score 0-3 (WHO standard) (6) Normal liver and kidney function: blood bilirubin =35µmol/L, AST/ALT less than 2 times the upper limit of normal value, blood creatinine =150µmol/L (7) Normal heart function
Exclusion criteria
Exclusion criteria: (1) Non-newly diagnosed AML patients (2) <18 years old (3) Second generation sequencing gene mutation detection and fusion gene detection were not performed at the first diagnosis (4) Patients undergoing allogeneic hematopoietic stem cell transplantation (5) Identify patients with central nervous system invasion (6) Women who are pregnant, planning to become pregnant or breastfeeding (7) Patients with other malignant tumors requiring treatment (8) Active TB patients and HIV-positive patients (9) Drug addiction or mental illness (10) Liver and kidney function was significantly abnormal, exceeding the inclusion criteria (11) Serious heart disease, including myocardial infarction and cardiac insufficiency (12) ECG results: QT interval greater than 450 ms (13) The sample quality is not qualified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Event-free lifetime; | — |
Countries
China
Contacts
Public ContactSong Yongping
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed