postoperative cognitive dysfunction
Conditions
Interventions
diabetic group:During the operation, the rSO2 values of diabetic patients were continuously monitored without targeted intervention.
non-diabetic group:During the operation, the rSO2 values of non-diabetic patients were continuously monitored without targeted intervention.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for major non-cardiac surgery under general anesthesia; 2. Age > 18 years; 3. ASA I-III; 4. Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients scheduled for brain surgery; 2. Preoperative MMSE score < 24; 3. Combined with neurological impairment or psychotic disorders; 4. Long-term use of sedatives or antipsychotics; 5. Alcohol or drug abuse; 6. Communication disorder; 7. Participating in other clinical investigators within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| regional cerebral oxygen saturation monitoring value;TLR4 expression in peripheral blood mononuclear cells;SF-8 questionnaire;CAM-ICU assessment;Demographics;Data retrieved for surgery and anesthesia ;Postoperative complications;Economic data; | — |
Countries
China
Contacts
Public ContactBo Gui
The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)
Outcome results
None listed