Postoperative myocardial injury
Conditions
Interventions
Low-level Group:For the low-level group: intraoperative MAP is maintained at 80%-100% of patients' baseline blood pressure.
High-level Group:For the high-level group: intraoperative MAP is maintained at 100%-120% of patients' baseline blood pressure.
Sponsors
First People's Hospital of Lianyungang City, Jiangsu Province
Eligibility
Sex/Gender
Female
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Aged 40-75 years. American Society of Anesthesiologists (ASA) physical status II-III. Elective radical mastectomy for breast cancer under general anesthesia. Receiving neoadjuvant chemotherapy before surgery. Able to voluntarily cooperate with this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: Patients with preoperative coexisting acute coronary syndrome or heart failure. Pre-operative coexistence of severe respiratory diseases and abnormalities of liver and kidney functions. Pre-operative coexisting mental and neurological diseases, such as epilepsy, Parkinson's disease, schizophrenia, etc. Body Mass Index (BMI) =18kg/m^2 or =30kg/m^2; Those with preoperative complications of severe infections that have been maintained with norepinephrine. Those with poorly controlled preoperative hypertension (systolic blood pressure = 180 mmHg and diastolic blood pressure = 110 mmHg). Emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of myocardial injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| HFABP;Kidney function;QoR-15 scores;PACU length of stay;Other postoperative cardiovascular complications (arrhythmia, myocardial infarction, lower extremity thrombosis, ischemic stroke, etc.);The number of times rescue analgesia and antiemetics were required;The time to first ambulation;Length of postoperative hospitalization; | — |
Countries
China
Contacts
Public ContactXiaobao Zhang
First People's Hospital of Lianyungang City, Jiangsu Province
Outcome results
None listed