Postoperative delirium
Conditions
Interventions
Experimental group:Esketamine is used for induction and maintenance and postoperative analgesia
Control group:Conventional drug
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1) Elderly patients (aged =60 years) undergoing elective knee/hip replacement; 2) ASA ?-? level; 3) Body Mass Index (BMI) 18-28kg/?
Exclusion criteria
Exclusion criteria: 1) The patient refused to participate in the study; 2) Patients with significantly elevated blood pressure that poses a serious risk (pheochromocytoma); 3) Allergic or contraindicated to the investigational drug; 4) A history of neurological or psychiatric diseases or inability to communicate; 5:) Patients who could not extubation and enter ICU after surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain;Postoperative recovery quality;Postoperative extubation time;The incidence of postoperative nausea and vomiting;MAP, heart rate, and BIS values.;Qor-15 rating;The incidence of nightmares and hallucinations; | — |
Countries
China
Contacts
Public ContactWang Zhongyu
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed