Influence of periodontitis-related cell-free DNA on atherosclerosis: A pilot study

The effect and mechanism of nucleic acid scavenger targeting regulation of periodontal disease-associated cfDNA on atherosclerosis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300077652

Enrollment

Unknown

Registered

2023-11-15

Start date

2023-11-20

Completion date

Unknown

Last updated

2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Periodontitis group:None

Periodontitis with atherosclerosis group:None

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Adults (>=18 years) 2. At least 14 natural teeth in the whole mouth; 3. The number of molars >= 4; 4. The patient's clinical data were complete

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. Oral local radiation therapy (such as head and neck therapy); 3. Suffering from major systemic diseases other than atherosclerosis/coronary heart disease (malignant tumors, acute myocardial infarction, acute cerebral infarction and other major systemic diseases); 4. Those who have serious dysfunction of heart, liver, kidney, lungs and other organs 5. Unable to sign informed consent.

Design outcomes

Primary

Measure	Time frame
cell-free DNA;	—

Secondary

Measure	Time frame
low density lipoprotein cholesterol;total cholesterol;high-density lipoprotein;very low density lipoprotein;	—

Countries

China

Contacts

Public ContactZhao Lei

West China Hospital of Stomatology, Sichuan University

jollyzldoc@163.com+86 135 5103 2465

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026