fMRI-navigated Transcranial Magnetic Stimulation (TMS) for mild cognitive impairment and early Alzheimer’s disease

Brain Health assessment, Early Screening, and Research on the Prevention and Treatment of Alzheimer's Disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077644

Enrollment

Unknown

Registered

2023-11-15

Start date

2023-11-15

Completion date

Unknown

Last updated

2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's disease

Interventions

mild AD:fMRI-navigated Transcranial Magnetic Stimulation (TMS)

MCI:fMRI-navigated Transcranial Magnetic Stimulation (TMS)

SMC:fMRI-navigated Transcranial Magnetic Stimulation (TMS)

normal cognitive aging:None

Eligibility

Sex/Gender

All

Age

55 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1 Mild Alzheimer's disease (AD): (1) Early and significant episodic memory impairments reported by the patient or informant. (2) Insidious onset, gradual progression, with a duration of =6 months. (3) Objective evidence of overall cognitive dysfunction and/or episodic memory impairment assessed using AD-specific cognitive scales. (4) Impairment in activities of daily living (ADL) due to cognitive dysfunction. (5) CDR score of 0.5 or 1. 2 Mild Cognitive Impairment (MCI): (1) Self-reported memory decline by the individual and/or informant. (2) Objective evidence of impairment on neuropsychological tests, particularly in memory (delayed recall = -1.5 SD). (3) Overall cognitive function is normal, with CDR score of 0 or 0.5. (4) Suspicious or mild impairments in instrumental activities of daily living and behavior. (5) Non-dementia condition. 3 Subjective Memory Complaints (SMC): (1) Self-reported memory decline by the individual and/or informant. (2) No objective evidence of impairment on neuropsychological tests (all relevant tests within the normal range). (3) Normal overall cognitive function, with CDR score of 0. 4Normal Cognitive Aging: (1) No self-reported memory decline by the individual or family members. (2) No objective evidence of impairment on neuropsychological tests (all relevant tests within the normal range). (3) Normal overall cognitive function, with CDR score of 0.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1. Acute onset with a duration of less than 6 months. 2. Early onset of severe gait disturbances, epilepsy, severe behavioral abnormalities, hallucinations, cognitive fluctuations, other extrapyramidal symptoms, or focal neurological signs. 3. Presence of non-degenerative cognitive impairment-related lesions or changes observed in imaging studies (e.g., MRI/CT). 4. Existence of secondary factors that could contribute to cognitive impairment, including but not limited to, traumatic brain injury, cerebrovascular disease, infections, metabolic disorders, endocrine disorders, and psychiatric/emotional factors. 5. Presence of contraindications for magnetic resonance imaging (MRI) and transcranial magnetic stimulation.

Design outcomes

Primary

Measure	Time frame
AVLT score;	—

Secondary

Measure	Time frame
fMRI;Other neuropsychological tests;blood AD markder;	—

Countries

China

Contacts

Public ContactLiang Gong

Chengdu Second People's Hospital

seugongliang@126.com+86 173 6025 1891

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026