perioperative neurocognitive disorders
Conditions
Interventions
Dex group :The patients are instructed to spray a loading dose of Dex into each nostril, 1-3 sprays per nostril, 30 minutes before bedtime. If the patient is still unable to fall asleep after 30 minut
Control group:In the control group, physiological saline is used instead of Dex and filled into the bottle (with no visual difference in appearance) as a placebo. 30 minutes before bedtime on the nigh
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective non-cardiac surgery under general anesthesia; 2. Anticipated surgery duration of >= 2 hours; 3. Aged >= 60 years; 4. Pittsburgh Sleep Quality Index (PSQI) score > 7; 5. Understanding of the informed consent form and agreement to participate in the study; 6. Ability to participate in neuropsychological testing with a Mini-Mental State Examination (MMSE) score >24.
Exclusion criteria
Exclusion criteria: 1. Allergy to the investigational drug; 2. Heart rate = IV; 5. Inability to receive nasal drug administration due to nasal, pharyngeal, or oral diseases; 6. Presence of severe neurological (e.g., stroke, intracranial tumors) or psychiatric disorders (e.g., schizophrenia, affective disorders); 7. Day surgeries or intracranial surgeries; 8. Patient withdrawal during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of delayed postoperative neurocognitive recovery;sleep quality; | — |
Countries
China
Contacts
Public ContactJing Shi
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed