glioma
Conditions
Interventions
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
5 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for stage WHO ?-? glioma group: 1) patients with primary glioma diagnosed by pathological diagnosis and WHO stage ?-? glioma. 2) subjects with no preoperative radiotherapy or chemotherapy. 3) subjects with complete clinical or laboratory data. 4) subjects had no other systemic diseases affecting urine composition. 5) the subjects were not associated with other central nervous system tumors or metastatic brain tumors and severe physical and mental disorders. 6) the subjects or guardians / legal representatives voluntarily cooperated with the study and signed the informed consent form. Inclusion criteria for stage WHO ?-? glioma group: 1) patients with primary glioma diagnosed by pathological diagnosis and WHO stage ?-? glioma. 2) subjects' age, sex, body mass index (BMI) matched with stage ?-? glioma group. 3) subjects had no history of preoperative radiotherapy or chemotherapy. 4) subjects had complete clinical or laboratory data. 5) the subjects had no other systemic diseases affecting the composition of urine. 6) the subjects were not associated with other central nervous system tumors or metastatic brain tumors and severe physical and mental disorders. 7) the subjects or guardians / legal representatives voluntarily cooperated with the study and signed an informed consent form. Inclusion criteria for meningioma group : 1) patients with primary meningioma who underwent surgical treatment for the first time and confirmed by pathological diagnosis. 2) age, sex and body mass index (BMI) matched with stage ?-? glioma group. 3) no preoperative radiotherapy or chemotherapy history. 4) complete clinical or laboratory data. 5) subjects had no other systemic diseases affecting urine composition. 6) the subjects were not associated with other central nervous system tumors or metastatic brain tumors and severe physical and mental disorders. 7) the subjects or guardians / legal representatives voluntarily cooperated with the study and signed an informed consent form. Inclusion criteria for healthy control group: 1) the routine laboratory tests of blood (blood routine, blood biochemistry, etc.), feces and urine (urine routine, urine protein, etc.) were normal, and no primary brain tumor or metastatic tumor was found by head CT examination. 2) the age, sex and body mass index (BMI) of the subjects matched those of stage ?-? gliomas. 3) the subjects can come from patients in the Health examination Center of Zhujiang Hospital or other departments who meet the admission requirements, so the cost of urine sampling is borne by this study. 4) the subjects' clinical data (admission, course of disease, discharge, etc.) or laboratory data are complete. 5) the subjects had no other systemic diseases affecting urine composition, such as severe kidney disease, urinary tract infection, liver disease, diabetes and other metabolic diseases. 6) the patients had no long-term history of smoking and drinking, no history of immunosuppressants, antiepileptic drugs, diuretics and other drugs for nearly a month. 7) the subjects were not complicated with severe somatic diseases and mental disorders. 8) the subject or guardian / legal representative voluntarily cooperated with the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1) the subjects were diagnosed with other central nervous system tumors or metastatic brain tumors. 2) the subjects were diagnosed with other systemic diseases affecting urine components, such as kidney disease, urinary tract infection, liver disease, metabolic disease, etc. 3) the subjects diagnosed other conditions affecting the expression of aquaporin 4 (AQP4), such as neuromyelitis spectrum disorder (NMOSD), multiple sclerosis (MS), ischemic stroke, etc. 4) the subjects have used drugs that affect the expression or metabolites of AQP4 in the past month, such as immunosuppressants, antiepileptic drugs, diuretics, etc. 5) the subjects are during pregnancy or lactation. 6) the subjects are unable to provide complete and reliable urine samples or the quality of urine samples is not up to standard. 7) there are conditions that other researchers think are not suitable to participate in the study, such as important complications, severe history of drug allergy, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence and level of specific metabolites in extracellular vesicles (EV) in urine of patients with glioma; | — |
Countries
China
Contacts
Public ContactSun Haitao
Zhujiang Hospital of Southern Medical University
Outcome results
None listed