Sleep-wake disorder
Conditions
Interventions
Dexmedetomidine group:Intraoperative epidural injection of 8ml mixture (formula: 7.5mg / ml ropivacaine + dexmedetomidine 1ug / mL), postoperative epidural analgesia pump, containing a mixture of 100
Control group :Intraoperative epidural injection of 8 mL mixture (formula: 7.5 mg / ml ropivacaine + 0.9 % normal saline of the same volume), postoperative epidural analgesia pump, containing 100 mL m
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women aged 20-45 years with full-term pregnancy; 2. Elective cesarean section under epidural anesthesia; 3. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. There is a clear history of mental disorders (depression, schizophrenia, etc.) or sleep disorders (such as insomnia, sleep apnea, etc.) before pregnancy, or taking analgesia, sedation, antidepressants; 2. Cognitive dysfunction or communication disorders; 3. There were severe pregnancy complications (such as severe preeclampsia, placenta accreta, HELLP syndrome, placenta previa, placental abruption,and those who undergo cervical cerclage due to a history of adverse pregnancy and childbirth), combined with severe organ dysfunction or endocrine diseases of heart, liver and kidney, or ASA grade >= III; 4. There are contraindications to the use of dexmedetomidine (such as hypotension, heart rate < 60 beats/min, cardiac conduction block, cardiac insufficiency, allergy to dexmedetomidine and its components);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of sleep disorders ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prenatal Pittsburgh sleep quality index(PSQI)score;NRS of subjective sleep quality score ;Prenatal Pittsburgh sleep quality index(PSQI) score and Insomnia Severity Index(ISI)score ;Edinburgh Postnatal Depression Scale(EPDS) score and Self-Rating Anxiety Scale(SAS)score ;Intraoperative pain score and sedation score;Postpartum hospital stay; | — |
Countries
China
Contacts
Public ContactLili Xu
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed