postoperation pain
Conditions
Interventions
Liposomal bupivacaine group:Liposome bupivacaine group (group L) : Prior to induction of anesthesia, 10ml of liposome bupivacaine (133mg) +10ml of normal saline were used for femoral nerve block on th
Standard bupivacaine group:Bupivacaine hydrochloride group (Group S) : 20 ml0.25% bupivacaine hydrochloride was used for femoral nerve block on the operative side before induction of anesthesia using
Mixed group:Mixed group (H) : Femoral nerve block with 10ml liposome bupivacaine +10ml 0.25% bupivacaine hydrochloride on the operative side was performed by ultrasound before induction of anesthesia
Sponsors
The First People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1)Clearly understand and voluntarily participate in the study, and sign the informed consent form; (2)Elective knee arthroplasty (operation duration = 2 hours; (3)ASA grade ?~?; (4)Consciousness, absence of cognitive dysfunction and other mental illnesses; (5) Stable condition and able to cooperate in completing the study.
Exclusion criteria
Exclusion criteria: 1)BMI 30 kg/m2; 2)Sensory deficits in the area of femoral nerve distribution; 3)Injection site infection; 4)Have taken a long-acting opioid within 3 days or any opioid within 24 hours before surgery; 5)Existing coagulopathy; 6)Recent (3 months) history of drug or alcohol abuse; 7)Known allergy to one of the study drugs; 8) Patients with acute and critical illnesses (including acute heart failure, acute stroke, acute myocardial infarction, severe infection, etc.); 9)Psychiatric or cognitive impairment that may interfere with perioperative assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores in postoperative recovery room, 48h, 72h resting state and active state;Total amount of anesthetic drugs and vasoactive drugs used during operation;Intraoperative hemodynamics;Time of first postoperative analgesia;The number of PCA compressions and the cumulative amount of postoperative analgesics used;The occurrence of rebound tenderness;hospital stays;Quadriceps femoris block; | — |
Countries
China
Contacts
Public ContactXiaobao Zhang
Department of Anesthesia, Lianyungang First People's Hospital
Outcome results
None listed