Helicobacter
Conditions
Interventions
B:Rabeprazole+Amoxicillin
A:Vonoprazan + Amoxicillin
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: Age 18-70 years old 2: Patients diagnosed with Helicobacter pylori positivity through 13C-UBT or 14C-UBT 3: Patients who have not received eradication treatment for Helicobacter pylori in the past, or who have failed eradication in the early stage but have not received eradication treatment within six months 4: Voluntarily participate in this experiment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1: Allergies to research drugs (such as those allergic to penicillin) 2: Patients with chronic gastritis accompanied by peptic ulcer 3: Patients who have received Helicobacter pylori eradication treatment within six months 4: Use antibiotics or bismuth medication 4 weeks before starting the study 5: use P-CAB or PPI 2 weeks before starting the study 6: Using corticosteroids, non steroidal anti-inflammatory drugs, or anticoagulants 7: History of esophageal or gastric surgery 8: Pregnant or lactating women 9: Suffering from serious concomitant diseases such as liver disease, cardiovascular disease, lung disease, or kidney disease 10: Excessive drinking; 11. Gastric mucosal associated lymphoid tissue lymphoma (MALT), malignant tumor disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate;Patient compliance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactZhang Zhenyu
Nanjing First Hospital
Outcome results
None listed