Postoperative pulmonary complications
Conditions
Interventions
Experimental group (Group P) :Experimental group (group P) : 10min before anesthesia induction, intravenous injection of penehyclidine hydrochloride 0.005mg/kg (diluted to 5ml with normal saline), and
control group (Group C):Control group (Group C) : The same volume of normal saline was given intravenously.
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Age >50 years old, ASA Grade II or III; 2)BMI=18.5kg/m2 ; 3)Non-cardiothoracic surgery is expected to take more than 2 hours; 4)According to the ARISCAT risk score, the cumulative ARISCAT score is =26; 5)Subjects agree to participate and sign informed consent.
Exclusion criteria
Exclusion criteria: 1)Patients who are unable to communicate pre-operatively due to neurocognitive dysfunction or language impairment; 2)Patients with unstable angina pectoris, myocardial infarction and heart failure within 3 months; 3)Patients requiring ventilator support or oxygen before surgery; 4)Patients with any cerebrovascular accident within 3 months, such as stroke, transient ischemic attack (TIA), etc; 5)Patients with severe liver dysfunction: Child-Pugh grade C; Patients with severe renal dysfunction: glomerular clearance 10 days within six months and have immune system disorders; 8)Patients with a history of major surgery within 1 month before the trial; 9)Patients with a history of major surgery within 1 month before the trial; 10)Patients with contraindications or allergies to experimental drugs and other narcotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary complications within 7 days (including 7 days) after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary ultrasound score: before anesthesia, 48h after surgery, 7d after surgery;CC-16, IL-8, TNF-a, CRP: before administration (T0), 60min after administration (T60), after surgery (Tend), 24h after surgery (T24h);Incidence of delirium 24h, 48h, 72h, and 7d after surgery;Incidence of nausea and vomiting at 24h, 48h and 72h after surgery;Pain score difference at 24h, 48h and 72h after surgery;Postoperative dry mouth, diplopia adverse reactions: 24h, 48h, 72h after surgery; | — |
Countries
China
Contacts
Public ContactYang Jian-Jun
The First Afliated Hospital of Zhengzhou University
Outcome results
None listed