Cardiovascular disease
Conditions
Interventions
control group:Taking a placebo
Intervention group:Taking dietary supplement S-adenosylmethionine
Sponsors
The Seventh Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: age 30-65 years 2: no gender restriction 3: Patients with carotid intima-media thickness were defined as those with carotid intima-media thickness greater than 0.9 mm on transcarotid ultrasound 4: basic reading ability, smart phone, ability to use social software such as wechat 5: to agree to participate in the study and actively cooperate with the participants to complete the follow-up, and to provide the informed consent signed by the participants
Exclusion criteria
Exclusion criteria: 1: patients who have had or are currently diagnosed with a tumor 2: a patient who is pregnant or who has been pregnant or breast-feeding in the past two years, or who plans to become pregnant within one year 3: AIDS patients 4: patients with unstable angina pectoris who suffered from acute myocardial infarction or underwent surgical operation within the last six months 5: those who are unable to perform and complete the intervention because of mental disorder, limb disability or other diseases or physical problems 6: has been, is or plans to participate in other clinical trials, weight-loss programs or other interventions, or is taking weight-loss drugs, or is receiving a clinical prescription diet 7: suffering from severe cardiovascular disease, diabetes, liver and kidney insufficiency 8: other conditions that prevent participation in the study or affect compliance 9: Concurrent use of Antidepressant, bipolar disorder, Parkinson's disease and other conditions related to SAM intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brachial artery endothelial function;The change value of carotid artery intima media thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| weight;height;Waist circumference;hip circumference;body fat percentage;Blood pressure;Oxidative stress level;SAM level;Routine blood indexes;Inflammatory factors; | — |
Countries
China
Contacts
Public ContactXiao Yunjun
The Seventh Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed