pancreatic tumour
Conditions
Interventions
mirabilite group:external application of mirabilite
control group:No
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
19 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Between the ages of 19 and 80 years, regardless of gender; ? Feasible standard pancreatic body tail resection or pancreaticoduodenectomy; ? Physical fitness score ECOG 0~2; ? Imaging examination reveals pancreatic body tail occupation, pancreatic head occupation, jugular abdominal occupation, and in case of malignant tumors, distant metastasis and ascites should not be detected; ? No obvious invasion of abdominal trunk and superior mesenteric artery; ? No obvious invasion of the abdominal trunk and superior mesenteric artery; ? No obvious contraindication to surgery; ? Expected postoperative survival = 3 months; ? Ability to comply with the study visit plan and other protocol requirements; ? Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: ? Localized unresectable pancreatic body tail adenocarcinoma (refer to the 2021 edition of the NCCN Pancreatic Cancer Guidelines); ? Requires combined organ/vascular resection (e.g., stomach, colon, celiac trunk, etc.); ? Total pancreatectomy is required; ? Those with distant metastasis or ascites detected by imaging; ? Those with severe impairment of cardiac, hepatic and renal functions (cardiac function grade 3 to 4, ALT and/or AST exceeding the upper limit of normal by more than 3 times, Cr exceeding the upper limit of normal); ? Combination of other malignant tumors or hematological diseases; ? Pregnant, planning to be pregnant and breastfeeding women (early pregnancy is diagnosed when urinary HCG>2500IU/L); ? Tumor resection prior to any manner of anti-tumor treatment, including interventional chemoembolization, ablation, radiotherapy, chemotherapy, and molecular targeted therapy; ? Clinical subjects who have participated in other pancreatic cancer treatments within three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of grade B and C pancreatic fistulae;Puncture drainage rate of abdominal fluid collection; | — |
Secondary
| Measure | Time frame |
|---|---|
| cost of hospitalization; Indicators of immune-related inflammation;visual analogue scale; | — |
Countries
China
Contacts
Public Contactshisi
Fudan University Shanghai Cancer Center
Outcome results
None listed