Stroke related cognitive impairment
Conditions
Interventions
True tDCS Stimulation Group:Stimulation Localization: The anode was placed above the left dorsolateral prefrontal cortex (DLPFC), while the cathode was placed near the right DLPFC .
Sham tDCS Stimulation Group:Sham transcranial direct current stimulation
Sponsors
Department of rehabilitation medicine, Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) It meets the diagnostic criteria of "stroke" [20], and all cases need to be confirmed as cerebral infarction or cerebral hemorrhage through clinical diagnosis and cranial CT or MRI examinations; (2) The patients' ages ranged from 30 to 75 years old, they experienced their first stroke within the past 1-6 months, their condition was stable, and their vital signs were stable; (3)Cognitive impairment occurs after a stroke, and the objective cognitive function assessment indicates the presence of cognitive impairment. However, the severity of cognitive impairment is not sufficient to prevent the patient from cooperating with the assessment and treatment (MoCA (Beijing version) total score of 10-26 points); (4) According to the Edinburgh Handedness scale (mean laterality score of 75%) [21], all subjects were right-handed; (5) Patients whose healthy side can measure the resting motor threshold; (6) The subjects themselves or their immediate family members signed the informed consent and voluntarily participated.
Exclusion criteria
Exclusion criteria: (1) The physical condition is unstable, and the function is reduced; (2) Have been pregnant or have a pregnancy plan in the next 3 months; (3) There are visual and hearing impairments or other factors affecting cognitive examination. (4) With a history of major mental disorders, diagnosed with dementia, autism spectrum disorder, or any other neurological disease except mild to moderate cognitive impairment, and diagnosed with bipolar disorder with manic or depressive episodes in the past year.; (5) They are currently in a state of moderate to severe depression or anxiety, with Hamilton Anxiety Scale (HAMA) = 14 points or Hamilton Depression Scale (HAMD) = 17 points; (6) Use of active drugs of the central nervous system or prescription or over-the-counter drugs (including benzodiazepines, anti-dementia drugs, cholinesterase inhibitors, etc.), abuse of any drugs (including nicotine and alcohol), or research drugs (baclofen and diazepam) ; (7) There are or have been serious adverse reactions to tDCS treatment; (8) TDCS contraindications (including epilepsy, tumor, VP shunt tube, metal implant, skull defect or crack, severe lung disease, multiple organ failure, etc.).;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination;modified Barthel index;interval intracortical inhibition;functional near-infra-red spectroscopy; | — |
Countries
China
Contacts
Public ContactZhang Qun
Department of rehabilitation medicine, Huashan Hospital, Fudan University
Outcome results
None listed