Obesity
Conditions
Interventions
Group S:Sufentanil + midazolam + propofol + remifentanil + Vecuronium bromide
Group D:Dexmedetomidine + Sufentanil + midazolam + propofol + remifentanil + Vecuronium bromide
Group ND:Nalbuphine + dexmedetomidine + Sufentanil + midazolam + propofol + remifentanil + Vecuronium bromide
Sponsors
Kunming Yan'an Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) BMI = 28kg/m2; (2) ASAI~III level; (3) Age 18-60 years old.
Exclusion criteria
Exclusion criteria: (1) Severe hypertension or hypotension; (2) Severe heart, lung, liver, and kidney functional diseases; (3) Individuals with a history of severe arrhythmia or sinus arrest; Patients with atrioventricular block and sinus bradycardia (preoperative HR<50 beats/minute) (4) Individuals who are allergic to dexmedetomidine or nabrphine; (5) Long term use of sedatives and analgesics; (6) Patients with difficulty in mask ventilation and severe obstructive sleep apnea syndrome are expected to require conscious intubation and planned to be sent to the ICU after surgery; (7) Individuals with a history of mental illness who are unable to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamics;Sedation-agitaion scale;Modified Minogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;NRS scale;PONV score;Athens insomnia scale; | — |
Countries
Chian
Contacts
Public ContactChen Yuqin
Kunming Yan'an Hospital
Outcome results
None listed