Poor ovarian response
Conditions
Interventions
Mind easing and menstruation normalizing acupuncture + IVF group:Mind easing and menstruation normalizing acupuncture + IVF
Non-meridian and non-acupoint acupuncture + IVF group:Non-meridian and non-acupoint acupuncture + IVF
IVF group:IVF patients receive ovulation promotion
Sponsors
Affiliated hospital of Chengdu university of traditional Chinese medicine
Eligibility
Sex/Gender
Female
Age
30 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Female, aged from 30 to 45; (Those who are 30-45 years old and meet the consensus ? and ? of ESHRE in the diagnosis of POR can be included.) 2.Consistent with the consensus of 2011ESHRE on the diagnosis of POR. 3.Consistent with the consensus of "Ministry of Health on Revising the Technical Specifications, Basic Standards and Ethical Principles Related to Human Assisted Reproductive Technology and Human Sperm Bank", in vitro fertilization-embryo transfer indications. 4.Subjects volunteered to participate in clinical trials and signed informed consent forms. Note: Those who meet the above four criteria will be considered for inclusion.
Exclusion criteria
Exclusion criteria: (1) abnormal reproductive function of the spouse; (2) unconscious, unable to express subjective discomfort symptoms, accompanied by severe depression, anxiety symptoms or mental illness; (3) allergic constitution or allergic to acupuncture; (4) Infertility due to fallopian tubes, female uterus does not have pregnancy function, and it has been confirmed that the reproductive organs have obvious or serious organic lesions or suffer from acute infection of reproductive and urinary systems or sexually transmitted diseases, chromosome abnormalities, and immune infertility; (5) Progressive malignant tumor or other serious consumptive diseases, which are easy to be complicated with infection and bleeding; (6) Patients with primary diseases such as cardiovascular disease, liver disease, kidney disease, digestive disease, hematopoietic system, etc. who can't bear pregnancy; (7) Exposure to teratogenic radiation, poisons, and drugs, which are in the effective period or have bad habits such as alcoholism and drug abuse; (8) Those who are currently participating in other clinical research projects. Note: Anyone who meets any one of the above items will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of retrieved oocytes;Fertilization rate;Rate of high quality embryos;Sex hormone levels;MicroRNA sequencing of peripheral blood;MicroRNA sequencing of follicular fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| SDS depression score;SAS anxiety score;Pittsburgh Sleep Index, PQSI;Kupperman score;Bax;Bcl2;Caspase; | — |
Countries
China
Contacts
Public ContactWu Jie
Affiliated hospital of Chengdu university of traditional Chinese medicine
Outcome results
None listed