Idiopathic hyperaldosteronism
Conditions
Interventions
Bilateral Intervention Group:Bilateral superselective adrenal artery embolization
Unilateral SAAE:Unilateral superselective adrenal artery embolization
Sponsors
The First Affiliated Hospital of Chengdu Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old, no gender limits. 2. Preparation. All antihypertensive drugs should be stopped at least 4 weeks. Verapamil (180-240 mg/d), prazosin (6-15 mg/d), and levamlodipine (2.5-5 mg/d) could be added in sequence when office blood pressure exceed 140/90 mmHg. Hypokalemia should be corrected with oral potassium chloride supplementation. Finally, patients with sitting blood pressure less than 160/100mmHg and serum potassium concentration exceeds 3.5mmol/L were screened for primary aldosteronism. 3. Aldosterone/renin activity ratio (ARR) >= 38 (pg/ml). 4. Primary aldosteronism confirmed by saline infusion test captopril test. 5. Bilateral adrenal hyperplasia or no obvious abnormality in CT image. 6. Adrenal vein blood sampling (AVS) is successful.
Exclusion criteria
Exclusion criteria: 1.Severe organic disease. 2. Pregnant and birth-giving women. 3. Myocardial infarction or stroke within 2 months, aortic dissection involving the abdominal aorta. 4. Other secondary hypertension. 5. Solitary mass >10 mm in lateralization of adrenal according to AVS, and aldosterone-producing adenoma cannot be excluded. 6. Serum creatinine =1.5mg/dl. 7. Severe contrast agent allergy. 8.Abnormal adrenal artery anatomy which is not suitable for SAAE.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Office blood pressure;Ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of antihypertensive drugs;Serum potassium;Serum sodium;Plasma renin;Plasma aldosterone; | — |
Countries
China
Contacts
Public ContactWang Peijian
The First Affiliated Hospital of Chengdu Medical College
Outcome results
None listed