Intravenous preinjection of acetaminophen reduces propofol injection pain: a single-center, double-blind, prospective, randomized controlled clinical study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077416

Enrollment

Unknown

Registered

2023-11-08

Start date

2023-07-01

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Propofol injection pain

Interventions

Acetaminophen group:Acetaminophen 2mg/kg

Esketamine group :Esketamine 0.2mg/kg

Lidocaine group:lidocaine injection 40mg

Normal saline group:Normal saline 15ml

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Age 18-60; (2) ASA grade I - II, patients to be treated with elective surgery under general anesthesia; (3) 18.5=BMI=24 kg/m2; (4) Can sign the informed consent by oneself

Exclusion criteria

Exclusion criteria: (1) Patients with diagnosed mental illness; (2) People who are known to be allergic to the drug under study; (3) Patients with severe heart, lung, liver or kidney dysfunction; (4) Severe hypertension or untreated hyperthyroidism; (5) Pregnancy or lactation; (6) Patients who have taken psychotropic drugs or analgesics for a long time

Design outcomes

Primary

Measure	Time frame
Propofol injection pain;	—

Secondary

Measure	Time frame
Incidence of heart rate abnormalities;Prevalence of abnormal blood pressure findings;The incidence rate of cardiac arrhythmia;	—

Countries

China

Contacts

Public ContactCh yong ming

Zijin People's Hospital, Heyuan City, Guangdong Province

741491691@qq.com+86 133 6098 7111

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026