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Effect of iPEEP on the PPCs for patients with preoperative cardiopulmonary function decline under CRS+HIPEC

Effect of iPEEP on the PPCs for patients with preoperative cardiopulmonary function decline under CRS+HIPEC

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077388
Enrollment
Unknown
Registered
2023-11-07
Start date
2023-11-10
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pulmonary complications

Interventions

N1:PEEP=5cmH2O
N2:Intraoperative PEEP was individualized by EIT titration

Sponsors

Beijing Shijitan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1) Age =18 years =90 years, 2) VSAQ score =7 points, 3) 7ml/kg/min=VO2max< 15ml/kg/min or 5ml/kg/min=AT< 11ml/kg/min, 4) peritoneal tumor cell reduction and thermoperfusion chemotherapy were to be performed during the operation, 5) BMI was less than or equal to 35,6) ASA grade I-III, 7) understood and signed the informed consent and volunteered to accept the clinical trial

Exclusion criteria

Exclusion criteria: 1) neuromusculoskeletal disease, 2) patients with serious cardiac disease before surgery (severe arrhythmia, history of myocardial infarction or heart failure within 1 month, severe valvular disease, aortic dissection), 3) acute upper respiratory tract or lung infection, uncontrolled asthma, moderate to massive pleural effusion within the last 2 weeks, 4) head, neck and chest malformation, 5) internal electrical activity implants, 6) active bleeding, 7) deep venous thrombosis of the lower extremities, 8) contraindications to general anesthesia, 9) inability to inform consent, and 10) patients deemed unfit by other investigators.

Design outcomes

Primary

MeasureTime frame
Cumulative incidence of postoperative pulmonary complications;

Secondary

MeasureTime frame
Postoperative cardiac complications;Respiratory mechanical parameter;ROI1,ROI2,ROI3,ROI4;Average length of stay;Arterial blood gas;

Countries

China

Contacts

Public ContactXiaonan Zhao

Beijing Shijitan Hospital, Capital Medical University

552047620@qq.com+86 138 1070 2521

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026